原著論文
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Machihara, T., Tanaka, H., Hayashi, Y., Murakami, I., and Namba, T *.
(2017) Questiomycin A stimulates sorafenib-induced cell death via
suppression of glucose-regulated protein 78. Biochemical and
biophysical research communications. 492, 33-40. (* Corresponding
author)
Namba, T. (2015) Regulation of endoplasmic reticulum functions. Aging (Albany NY) 7, 901-902
Byun, S., Namba, T., and Lee, S. W. (2015) Losing p53 loosens up ER-stress. Aging (Albany NY) 7, 895-896
Hiraki, M., Hwang, S. Y., Cao, S., Ramadhar, T. R., Byun, S., Yoon, K. W., Lee, J. H., Chu, K., Gurkar, A. U., Kolev, V., Zhang, J., Namba, T., Murphy, M. E., Newman, D. J., Mandinova, A., Clardy, J., and Lee, S. W. (2015) Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol 22, 1206-1216
Namba, T *., Chu, K., Kodama, K., Byun, S., Yoon, KW., Hiraki, M., Mandinova, A., and Sam W. Lee*. (2015) Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway. Oncotarget 6, 19990-20001 (* Corresponding author) “priority research paper に選出” “カナダの医学・生物学系情報サイトGlobal Medical Discovery(http://globalmedicaldiscovery.com) [ISSN 1929-8536] の重要科学論文（Key Scientific Articles）の1つに選出” “高知新聞に掲載”
Namba, T *., Kodama, R., Moritomo, S., Hoshino, T., and Mizushima, T. (2015) Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3beta-Snail pathway. Cell death & disease 6, e1795 (* Corresponding author)
Namba, T *., and Kodama, R. (2015) Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2alpha-CHOP signaling. Marine drugs 13, 2376-2389 (* Corresponding author)
Kakigano, A., Tomimatsu, T., Mimura, K., Kanayama, T., Fujita, S., Minato, K., Kumasawa, K., Taniguchi, Y., Kanagawa, T., Endo, M., Ishihara, T., Namba, T., Mizushima, T., and Kimura, T. (2015) Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor. Reproductive sciences. in press
Namba, T., Tian, F., Chu, K., Hwang, S. Y., Yoon, K. W., Byun, S., Hiraki, M., Mandinova, A., and Lee, S. W. (2013) CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Cell Reports 5, 331-339
Tanaka, K., Shirai, A., Ito, Y., Namb, T., Tahara, K., Yamakawa, N., and Mizushima, T. (2012) Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice. Biochemical and Biophysical Research Communications 425, 818-824
Hoshino, T., Namba, T., Takehara, M., Murao, N., Matsushima, T., Sugimoto, Y., Narumiya, S., Suzuki, T., and Mizushima, T. (2012) Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. Journal of Neurochemistry 120, 795-805
Brown-Endres, L., Schoenfeld, D., Tian, F., Kim, H. G., Namba, T., Munoz-Fontela, C., Mandinova, A., Aaronson, S. A., and Lee, S. W. (2012) Expression of the p53 target CDIP correlates with sensitivity to TNFalpha-induced apoptosis in cancer cells. Cancer Research 72, 2373-2382
Tanaka, K., Tanaka, Y., Miyazaki, Y., Namba, T., Sato, K., Aoshiba, K., Azuma, A., and Mizushima, T. (2011) Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema. The Journal of Pharmacology and Experimental Therapeutics 338, 810-818
Takehara, M., Hoshino, T., Namba, T., Yamakawa, N., and Mizushima, T. (2011) Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice. Biochemical Pharmacology 81, 1124-1135
Namba, T., Tanaka, K., Hoshino, T., Azuma, A., and Mizushima, T. (2011) Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PloS one 6, e27296
Hoshino, T., Murao, N., Namba, T., Takehara, M., Adachi, H., Katsuno, M., Sobue, G., Matsushima, T., Suzuki, T., and Mizushima, T. (2011) Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. The Journal of Neuroscience 31, 5225-5234
Tanaka, K., Tanaka, Y., Namba, T., Azuma, A., and Mizushima, T. (2010) Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. Biochemical Pharmacology 80, 920-931
Tanaka, K., Ishihara, T., Azuma, A., Kudoh, S., Ebina, M., Nukiwa, T., Sugiyama, Y., Tasaka, Y., Namba, T., Ishihara, T., Sato, K., Mizushima, Y., and Mizushima, T. (2010) Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis. American Journal of Physiology. Lung cellular and molecular physiology 298, L348-360
Namba, T., Tanaka, K. I., Ito, Y., Hoshino, T., Matoyama, M., Yamakawa, N., Isohama, Y., Azuma, A., and Mizushima, T. (2010) Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. Cell Death and Differentiation 17, 1882-1895
Namba, T., Hoshino, T., Suemasu, S., Takarada-Iemata, M., Hori, O., Nakagata, N., Yanaka, A., and Mizushima, T. (2010) Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions. The Journal of Biological Chemistry 285, 37302-37313
Suemasu, S., Tanaka, K., Namba, T., Ishihara, T., Katsu, T., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2009) A role for HSP70 in protecting against indomethacin-induced gastric lesions. The Journal of Biological Chemistry 284, 19705-19715
Namba, T., Tanaka, K., Ito, Y., Ishihara, T., Hoshino, T., Gotoh, T., Endo, M., Sato, K., and Mizushima, T. (2009) Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. The American Journal of Pathology 174, 1786-1798
Namba, T., Homan, T., Nishimura, T., Mima, S., Hoshino, T., and Mizushima, T. (2009) Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in anti-tumorigenic effects. The Journal of Biological Chemistry 284, 4158-4167
Ishihara, T., Tanaka, K., Tasaka, Y., Namba, T., Suzuki, J., Ishihara, T., Okamoto, S., Hibi, T., Takenaga, M., Igarashi, R., Sato, K., Mizushima, Y., and Mizushima, T. (2009) Therapeutic effect of lecithinized superoxide dismutase against colitis. The Journal of Pharmacology and Experimental Therapeutics 328, 152-164
Hoshino, T., Namba, T., Takehara, M., Nakaya, T., Sugimoto, Y., Araki, W., Narumiya, S., Suzuki, T., and Mizushima, T. (2009) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. The Journal of Biological Chemistry 284, 18493-18502
Ushijima, H., Hiasa, M., Namba, T., Hwang, H. J., Hoshino, T., Mima, S., Tsuchiya, T., Moriyama, Y., and Mizushima, T. (2008) Expression and function of TETRAN, a new type of membrane transporter. Biochemical and Biophysical Research Communications 374, 325-330
Tanaka, K., Namba, T., Arai, Y., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2007) Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. The Journal of Biological Chemistry 282, 23240-23252
Namba, T., Ishihara, T., Tanaka, K., Hoshino, T., and Mizushima, T. (2007) Transcriptional activation of ATF6 by endoplasmic reticulum stressors. Biochemical and Biophysical Research Communications 355, 543-548
Namba, T., Hoshino, T., Tanaka, K., Tsutsumi, S., Ishihara, T., Mima, S., Suzuki, K., Ogawa, S., and Mizushima, T. (2007) Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. Molecular Pharmacology 71, 860-870
Ishihara, T., Hoshino, T., Namba, T., Tanaka, K., and Mizushima, T. (2007) Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis. Biochemical and Biophysical Research Communications 356, 711-717
Tsutsumi, S., Namba, T., Tanaka, K. I., Arai, Y., Ishihara, T., Aburaya, M., Mima, S., Hoshino, T., and Mizushima, T. (2006) Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells. Oncogene 25, 1018-1029
Tanaka, K., Tomisato, W., Hoshino, T., Ishihara, T., Namba, T., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S., and Mizushima, T. (2005) Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis. The Journal of Biological Chemistry 280, 31059-31067
受賞
- 第９回臨床ストレス応答学会 若手奨励賞 (2014)
- AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award. (The AACR Annual Meeting 2013)
Travel Grant Award. (The 15th Congress of the Asian Pacific Society of Respiratory 2010.)